Abstract: This study aims to establish a comprehensive evaluation system for assessing the effectiveness of ecological restoration projects in coastal wetlands in the Pearl River Estuary, and to apply it to five typical projects. Five coastal wetland restoration projects (Shenzhen Bay, Dongchong Wetland, Qianhai Guiwan, Mangzhou Wetland, and Humen Waterway) were selected as study objects. Using the Analytic Hierarchy Process (AHP), a comprehensive evaluation model was constructed from three dimensions: project implementation, biological recovery, and habitat restoration, involving 14 indicators. The results show that the comprehensive scores were 88.63 for Dongchong Wetland and 87.26 for Humen Waterway (rated as “excellent”), 78.65 for Shenzhen Bay (“good”), and 67.02 and 74.99 for Qianhai Guiwan and Mangzhou Wetland, respectively (“qualified”). Biological recovery had the greatest impact on the overall evaluation (weight 0.369 6), with plant adaptability and native mangrove index being the key factors. The established evaluation system is operational and representative, providing technical and decision-making support for the ecological restoration of coastal wetlands in China.